Microsoft closed its E3 press conference with a look at 343 Industries Halo 4. The short teaser showed where Master Chief left off, in hibernation, being woken up by Cortana and surrounded by the ensuing wreckage of his ship.
The trailer closed with a Holiday 2012 release and effectively begins the new trilogy for the Halo series. The ship hints at Forerunner technology so who knows what we will have to contend with in the way forward.